SCOPe 2.04: Domain d4cbtc_: 4cbt C:

Lineage for d4cbtc_ (4cbt C:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein automated matches [190786] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188039] (20 PDB entries)

8. Domain d4cbtc_: 4cbt C: [251361]
   automated match to d4cbyd_
   complexed with 9f4, zn

Details for d4cbtc_

PDB Entry: 4cbt, 3.03 Å

PDB Description: design, synthesis, and biological evaluation of potent and selective class iia hdac inhibitors as a potential therapy for huntington's disease

PDB Compounds: (C:) Histone deacetylase 4

SCOPe Domain Sequences for d4cbtc_:

Sequence, based on SEQRES records:

>d4cbtc_ c.42.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gstkprfttglvydtlmlkhqctcgsssshpehagriqsiwsrlqetglrgkcecirgrk
atleelqtvhseahtllygtnplnrqkldskkllgslasvfvrlpcggvgvdsdtiwnev
hsagaarlavgcvvelvfkvatgelkngfavvrppghhaeestpmgfcyfnsvavaakll
qqrlsvskilivdwdvhhgngtqqafysdpsvlymslhryddgnffpgsgapdevgtgpg
vgfnvnmaftggldppmgdaeylaafrtvvmpiasefapdvvlvssgfdaveghptplgg
ynlsarcfgyltkqlmglaggrivlalegghdltaicdaseacvsallgneldplpekvl
qqrpnanavrsmekvmeihskywrclqrh

Sequence, based on observed residues (ATOM records):

>d4cbtc_ c.42.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gstkprfttglvydtlmlkhqctcshpehagriqsiwsrlqetglrgkcecirgrkatle
elqtvhseahtllygtnpltiwnevhsagaarlavgcvvelvfkvatgelkngfavvrpp
ghhaeestpmgfcyfnsvavaakllqqrlskilivdwdvhhgngtqqafysdpsvlymsl
hryddgnffpgsgapdevgtgpgvgfnvnmaftggldppmgdaeylaafrtvvmpiasef
apdvvlvssgfdaveghptplggynlsarcfgyltkqlmglaggrivlalegghdltaic
daseacvsallgnekvlqqrpnanavrsmekvmeihskywrclqrh

Timeline for d4cbtc_:

• d4cbtc_ is new in SCOPe 2.04-stable
  
• d4cbtc_ appears in SCOPe 2.05
  
• d4cbtc_ appears in the current release, SCOPe 2.08, called d4cbtc1