SCOPe 2.08: Domain d4cbta1: 4cbt A:650-1033

Lineage for d4cbta1 (4cbt A:650-1033)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein automated matches [190786] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188039] (41 PDB entries)

8. Domain d4cbta1: 4cbt A:650-1033 [251359]
   Other proteins in same PDB: d4cbta2, d4cbtc2, d4cbtc3
   automated match to d4cbyd_
   complexed with 9f4, zn

Details for d4cbta1

PDB Entry: 4cbt, 3.03 Å

PDB Description: design, synthesis, and biological evaluation of potent and selective class iia hdac inhibitors as a potential therapy for huntington's disease

PDB Compounds: (A:) Histone deacetylase 4

SCOPe Domain Sequences for d4cbta1:

Sequence, based on SEQRES records:

>d4cbta1 c.42.1.2 (A:650-1033) automated matches {Human (Homo sapiens) [TaxId: 9606]}
prfttglvydtlmlkhqctcgsssshpehagriqsiwsrlqetglrgkcecirgrkatle
elqtvhseahtllygtnplnrqkldskkllgslasvfvrlpcggvgvdsdtiwnevhsag
aarlavgcvvelvfkvatgelkngfavvrppghhaeestpmgfcyfnsvavaakllqqrl
svskilivdwdvhhgngtqqafysdpsvlymslhryddgnffpgsgapdevgtgpgvgfn
vnmaftggldppmgdaeylaafrtvvmpiasefapdvvlvssgfdaveghptplggynls
arcfgyltkqlmglaggrivlalegghdltaicdaseacvsallgneldplpekvlqqrp
nanavrsmekvmeihskywrclqr

Sequence, based on observed residues (ATOM records):

>d4cbta1 c.42.1.2 (A:650-1033) automated matches {Human (Homo sapiens) [TaxId: 9606]}
prfttglvydtlmlkhqctcgsssshpehagriqsiwsrlqetglrgkcecirgrkatle
elqtvhseahtllygtnplsdtiwnevhsagaarlavgcvvelvfkvatgelkngfavvr
ppghhaeestpmgfcyfnsvavaakllqqrlsvskilivdwdvhhgngtqqafysdpsvl
ymslhryddgnffpgsgapdevgtgpgvgfnvnmaftggldppmgdaeylaafrtvvmpi
asefapdvvlvssgfdaveghptplggynlsarcfgyltkqlmglaggrivlalegghdl
taicdaseacvsallgnellqqrpnanavrsmekvmeihskywrclqr

Timeline for d4cbta1:

• d4cbta1 first appeared in SCOPe 2.04, called d4cbta_
  
• d4cbta1 appears in SCOPe 2.07