SCOPe 2.08: Domain d4bdfa1: 4bdf A:210-512

Lineage for d4bdfa1 (4bdf A:210-512)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4bdfa1: 4bdf A:210-512 [251218]
   Other proteins in same PDB: d4bdfa2
   automated match to d2ycfa_
   complexed with edo, h3r, no3

Details for d4bdfa1

PDB Entry: 4bdf, 2.7 Å

PDB Description: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)

PDB Compounds: (A:) serine/threonine-protein kinase chk2

SCOPe Domain Sequences for d4bdfa1:

Sequence, based on SEQRES records:

>d4bdfa1 d.144.1.0 (A:210-512) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpaln
veteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfy
qmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtpt
ylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfip
evwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestalp
qvl

Sequence, based on observed residues (ATOM records):

>d4bdfa1 d.144.1.0 (A:210-512) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svypkalrdeyimsktlggevklaferktckkvaikiisknveteieilkklnhpciiki
knffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiihrdl
kpenvllssqeedclikitdfghskilgetslmrtlcgtptylapevlvsvgtagynrav
dcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkkllv
vdpkarftteealrhpwlqdedmkrkfqdllseenestalpqvl

Timeline for d4bdfa1:

• d4bdfa1 first appeared in SCOPe 2.04, called d4bdfa_
  
• d4bdfa1 appears in SCOPe 2.07