SCOPe 2.05: Domain d4bdca_: 4bdc A:

Lineage for d4bdca_ (4bdc A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (21 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (615 PDB entries)

8. Domain d4bdca_: 4bdc A: [251215]
   automated match to d2ycfa_
   complexed with cl, edo, no3, odh

Details for d4bdca_

PDB Entry: 4bdc, 3 Å

PDB Description: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)

PDB Compounds: (A:) serine/threonine-protein kinase chk2

SCOPe Domain Sequences for d4bdca_:

Sequence, based on SEQRES records:

>d4bdca_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpaln
veteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfy
qmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtpt
ylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfip
evwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestalp
qvl

Sequence, based on observed residues (ATOM records):

>d4bdca_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svypkalrdeyimsktlgsevklaferktckkvaikiisknveteieilkklnhpciiki
knffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiihrdl
kpenvllssqeedclikitdfghskiletslmrtlcgtptylapevlvsvgtagynravd
cwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkkllvv
dpkarftteealrhpwlqdedmkrkfqdllseenestalpqvl

Timeline for d4bdca_:

• d4bdca_ first appeared in SCOPe 2.04
  
• d4bdca_ appears in SCOPe 2.06
  
• d4bdca_ appears in the current release, SCOPe 2.08