SCOPe 2.04: Domain d4anva4: 4anv A:726-1089

Lineage for d4anva4 (4anv A:726-1089)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (19 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (476 PDB entries)

8. Domain d4anva4: 4anv A:726-1089 [251086]
   Other proteins in same PDB: d4anva1, d4anva2, d4anva3
   automated match to d1e7ua4
   complexed with 751, so4

Details for d4anva4

PDB Entry: 4anv, 2.13 Å

PDB Description: Complexes of PI3Kgamma with isoform selective inhibitors.

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4anva4:

Sequence, based on SEQRES records:

>d4anva4 d.144.1.0 (A:726-1089) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpeltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflh

Sequence, based on observed residues (ATOM records):

>d4anva4 d.144.1.0 (A:726-1089) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaevssqvisqlkqklenlqnsqlpesfrvpyd
pglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqil
rimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevln
hwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghi
kervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgm
peltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflh

Timeline for d4anva4:

• d4anva4 is new in SCOPe 2.04-stable
  
• d4anva4 appears in SCOPe 2.05
  
• d4anva4 appears in the current release, SCOPe 2.08