SCOPe 2.06: Domain d4agda_: 4agd A:

Lineage for d4agda_ (4agd A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (17 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)

8. Domain d4agda_: 4agd A: [251025]
   automated match to d3vo3a_
   complexed with b49

Details for d4agda_

PDB Entry: 4agd, 2.81 Å

PDB Description: crystal structure of vegfr2 (juxtamembrane and kinase domains) in complex with sunitinib (su11248) (n-2-diethylaminoethyl)-5-((z)-(5- fluoro-2-oxo-1h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3- carboxamide)

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d4agda_:

Sequence, based on SEQRES records:

>d4agda_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lsivmdpdelpldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktat
crtvavkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckf
gnlstylrskrnefvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaa
rnillseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsf
gvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrp
tfselvehlgnllqanaq

Sequence, based on observed residues (ATOM records):

>d4agda_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lsivmdpdelplpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavk
mlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstyl
rskrnefvpyykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkic
dfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgasp
ypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllq
anaq

Timeline for d4agda_:

• d4agda_ first appeared in SCOPe 2.04
  
• d4agda_ appears in SCOPe 2.05
  
• d4agda_ appears in SCOPe 2.07
  
• d4agda_ appears in the current release, SCOPe 2.08