Lineage for d4agda_ (4agd A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1931583Protein automated matches [190091] (12 species)
    not a true protein
  7. 1931656Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)
  8. 1932230Domain d4agda_: 4agd A: [251025]
    automated match to d3vo3a_
    complexed with b49

Details for d4agda_

PDB Entry: 4agd (more details), 2.81 Å

PDB Description: crystal structure of vegfr2 (juxtamembrane and kinase domains) in complex with sunitinib (su11248) (n-2-diethylaminoethyl)-5-((z)-(5- fluoro-2-oxo-1h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3- carboxamide)
PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d4agda_:

Sequence, based on SEQRES records: (download)

>d4agda_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lsivmdpdelpldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktat
crtvavkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckf
gnlstylrskrnefvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaa
rnillseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsf
gvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrp
tfselvehlgnllqanaq

Sequence, based on observed residues (ATOM records): (download)

>d4agda_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lsivmdpdelplpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavk
mlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstyl
rskrnefvpyykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkic
dfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgasp
ypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllq
anaq

SCOPe Domain Coordinates for d4agda_:

Click to download the PDB-style file with coordinates for d4agda_.
(The format of our PDB-style files is described here.)

Timeline for d4agda_: