Lineage for d4agca_ (4agc A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2545120Protein automated matches [190091] (20 species)
    not a true protein
  7. 2545220Species Human (Homo sapiens) [TaxId:9606] [188447] (770 PDB entries)
  8. 2545363Domain d4agca_: 4agc A: [251024]
    automated match to d3vo3a_
    complexed with axi

Details for d4agca_

PDB Entry: 4agc (more details), 2 Å

PDB Description: crystal structure of vegfr2 (juxtamembrane and kinase domains) in complex with axitinib (ag-013736) (n-methyl-2-(3-((e)-2-pyridin-2-yl- vinyl)-1h-indazol-6-ylsulfanyl)-benzamide)
PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d4agca_:

Sequence, based on SEQRES records: (download)

>d4agca_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ylsivmdpdelpldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidkta
tcrtvavkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefck
fgnlstylrskrnefvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdla
arnillseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvws
fgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqr
ptfselvehlgnllqanaq

Sequence, based on observed residues (ATOM records): (download)

>d4agca_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ylsivmdpdelplpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvav
kmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlsty
lrskrnefvpyykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaq

SCOPe Domain Coordinates for d4agca_:

Click to download the PDB-style file with coordinates for d4agca_.
(The format of our PDB-style files is described here.)

Timeline for d4agca_: