SCOPe 2.05: Domain d3vs7b2: 3vs7 B:147-249

Lineage for d3vs7b2 (3vs7 B:147-249)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.0: automated matches [191409] (1 protein)
   not a true family

6. Protein automated matches [190561] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187549] (41 PDB entries)

8. Domain d3vs7b2: 3vs7 B:147-249 [250674]
   Other proteins in same PDB: d3vs7a1, d3vs7a3, d3vs7b1, d3vs7b3
   automated match to d1fmka2
   complexed with ca, cl, ks1

Details for d3vs7b2

PDB Entry: 3vs7, 3 Å

PDB Description: Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

PDB Compounds: (B:) Tyrosine-protein kinase HCK

SCOPe Domain Sequences for d3vs7b2:

Sequence, based on SEQRES records:

>d3vs7b2 d.93.1.0 (B:147-249) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhykir
tldnggfyisprstfstlqelvdhykkgndglcqklsvpcmss

Sequence, based on observed residues (ATOM records):

>d3vs7b2 d.93.1.0 (B:147-249) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhykir
tfyisprstfstlqelvdhykkgndglcqklsvpcmss

Timeline for d3vs7b2:

• d3vs7b2 first appeared in SCOPe 2.04
  
• d3vs7b2 appears in SCOPe 2.06
  
• d3vs7b2 appears in the current release, SCOPe 2.08