SCOPe 2.07: Domain d3sclb_: 3scl B:

Lineage for d3sclb_ (3scl B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

6. Protein Angiotensin converting enzyme 2, ACE2 [103125] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [103126] (20 PDB entries)

8. Domain d3sclb_: 3scl B: [249352]
   Other proteins in same PDB: d3scle_, d3sclf_
   automated match to d3d0ga_
   complexed with cl, zn

Details for d3sclb_

PDB Entry: 3scl, 3 Å

PDB Description: crystal structure of spike protein receptor-binding domain from sars coronavirus epidemic strain complexed with human-civet chimeric receptor ace2

PDB Compounds: (B:) Angiotensin-converting enzyme 2 chimera

SCOPe Domain Sequences for d3sclb_:

Sequence; same for both SEQRES and ATOM records:

>d3sclb_ d.92.1.5 (B:) Angiotensin converting enzyme 2, ACE2 {Human (Homo sapiens) [TaxId: 9606]}
stteelaktfletfnyeaqelsyqssvaswnyntniteenvqnmnnagdkwsaflkeqst
laqtyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad

Timeline for d3sclb_:

• d3sclb_ first appeared in SCOPe 2.04
  
• d3sclb_ appears in SCOPe 2.06
  
• d3sclb_ appears in the current release, SCOPe 2.08