SCOPe 2.08: Domain d3qgea_: 3qge A:

Lineage for d3qgea_ (3qge A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d3qgea_: 3qge A: [248881]
   automated match to d3q0za_
   protein/RNA complex; complexed with 23e, 26f, so4

Details for d3qgea_

PDB Entry: 3qge, 3 Å

PDB Description: Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3qgea_:

Sequence, based on SEQRES records:

>d3qgea_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhir
svwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkaa
aacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpip
aasqldlsswfvagysggdiyhsl

Sequence, based on observed residues (ATOM records):

>d3qgea_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakll
sveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakne
vfcvqpekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrvef
lvnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyig
gpltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvvi
cesagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvyy
ltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekal
dcqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrhr
arsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyhs
l

Timeline for d3qgea_:

• d3qgea_ first appeared in SCOPe 2.04
  
• d3qgea_ appears in SCOPe 2.07