SCOPe 2.05: Domain d3prea2: 3pre A:353-522

Lineage for d3prea2 (3pre A:353-522)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (57 PDB entries)

8. Domain d3prea2: 3pre A:353-522 [248624]
   Other proteins in same PDB: d3prea1, d3prea3, d3prea4
   automated match to d1e8wa2
   complexed with 3re

Details for d3prea2

PDB Entry: 3pre, 2.91 Å

PDB Description: quinazolines with intra-molecular hydrogen bonding scaffold (imhbs) as pi3k/mtor dual inhibitors.

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3prea2:

Sequence, based on SEQRES records:

>d3prea2 b.7.1.1 (A:353-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
slwdcdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnv
wlefsikikdlpkgallnlqiycgkapalsskasaespsseskgkvqllyyvnlllidhr
fllrrgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d3prea2 b.7.1.1 (A:353-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
slwdcdrkfrvkirgidipvlltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefs
ikikdlpkgallnlqiycvqllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsat
npdkensmsisilldn

Timeline for d3prea2:

• d3prea2 first appeared in SCOPe 2.04
  
• d3prea2 appears in SCOPe 2.06
  
• d3prea2 appears in the current release, SCOPe 2.08