SCOPe 2.07: Domain d3nzua4: 3nzu A:726-1094

Lineage for d3nzua4 (3nzu A:726-1094)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d3nzua4: 3nzu A:726-1094 [248110]
   Other proteins in same PDB: d3nzua1, d3nzua2, d3nzua3
   automated match to d1e7ua4
   complexed with nzu

Details for d3nzua4

PDB Entry: 3nzu, 2.6 Å

PDB Description: Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3nzua4:

Sequence, based on SEQRES records:

>d3nzua4 d.144.1.4 (A:726-1094) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlvlgi

Sequence, based on observed residues (ATOM records):

>d3nzua4 d.144.1.4 (A:726-1094) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslydvssqvisqlkqklenlqnsqlpesfrvpydp
glkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilr
imesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnh
wlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghil
gnyrvpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtg
mpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgi

Timeline for d3nzua4:

• d3nzua4 first appeared in SCOPe 2.04
  
• d3nzua4 appears in SCOPe 2.06
  
• d3nzua4 appears in the current release, SCOPe 2.08