SCOPe 2.07: Domain d3l08a3: 3l08 A:527-725

Lineage for d3l08a3 (3l08 A:527-725)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (27 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   automatically mapped to Pfam PF00613
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (77 PDB entries)

8. Domain d3l08a3: 3l08 A:527-725 [247309]
   Other proteins in same PDB: d3l08a1, d3l08a2, d3l08a4
   automated match to d1e7ua1
   complexed with so4, zig

Details for d3l08a3

PDB Entry: 3l08, 2.7 Å

PDB Description: structure of pi3k gamma with a potent inhibitor: gsk2126458

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3l08a3:

Sequence, based on SEQRES records:

>d3l08a3 a.118.1.6 (A:527-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
ialpkhqptpdpegdrvraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhp
kaypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavq
klesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqs
rhyqqrfavileaylrgcg

Sequence, based on observed residues (ATOM records):

>d3l08a3 a.118.1.6 (A:527-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
ialpkhqraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssv
kwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddv
lhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavi
leaylrgcg

Timeline for d3l08a3:

• d3l08a3 first appeared in SCOPe 2.04
  
• d3l08a3 appears in SCOPe 2.06
  
• d3l08a3 appears in the current release, SCOPe 2.08