SCOPe 2.05: Domain d3gznc_: 3gzn C:

Lineage for d3gznc_ (3gzn C:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
   the common fold is elaborated with additional (sub)domains

6. Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

7. Species Human (Homo sapiens) [TaxId:9606] [89767] (9 PDB entries)
   Uniprot Q13564

8. Domain d3gznc_: 3gzn C: [246398]
   Other proteins in same PDB: d3gznb_, d3gznd_, d3gzni_, d3gznj_
   automated match to d1tt5a_
   complexed with b39, zn

Details for d3gznc_

PDB Entry: 3gzn, 3 Å

PDB Description: Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924

PDB Compounds: (C:) NEDD8-activating enzyme E1 regulatory subunit

SCOPe Domain Sequences for d3gznc_:

Sequence, based on SEQRES records:

>d3gznc_ c.111.1.2 (C:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
llkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqvs
gedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftvv
vatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrld
kpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykekedfrdl
irqgilknengapedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwi
laralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllq
sigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivly
lmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcryg
aaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

Sequence, based on observed residues (ATOM records):

>d3gznc_ c.111.1.2 (C:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
llkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqvs
gedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftvv
vatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrld
kpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetripktykekedfrdlir
qgilknengapedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwila
ralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsi
gqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylm
lravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaa
ephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

Timeline for d3gznc_:

• d3gznc_ first appeared in SCOPe 2.04
  
• d3gznc_ appears in SCOPe 2.06
  
• d3gznc_ appears in the current release, SCOPe 2.08