Lineage for d3ey4b_ (3ey4 B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2090580Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2090596Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845
  8. 2090689Domain d3ey4b_: 3ey4 B: [245989]
    automated match to d3pdjb_
    complexed with 352, ndp

Details for d3ey4b_

PDB Entry: 3ey4 (more details), 3 Å

PDB Description: Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
PDB Compounds: (B:) 11-beta-hydroxysteroid dehydrogenase 1

SCOPe Domain Sequences for d3ey4b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3ey4b_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3ey4b_:

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(The format of our PDB-style files is described here.)

Timeline for d3ey4b_: