SCOPe 2.04: Domain d3exfd1: 3exf D:1-191

Lineage for d3exfd1 (3exf D:1-191)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
   automatically mapped to Pfam PF02779

6. Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89653] (4 PDB entries)

8. Domain d3exfd1: 3exf D:1-191 [245932]
   Other proteins in same PDB: d3exfa_, d3exfb2, d3exfc_, d3exfd2, d3exfe_, d3exff2, d3exfg_, d3exfh2
   automated match to d2ozlb1
   complexed with k, mg, tpp

Details for d3exfd1

PDB Entry: 3exf, 3 Å

PDB Description: crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex

PDB Compounds: (D:) Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

SCOPe Domain Sequences for d3exfd1:

Sequence; same for both SEQRES and ATOM records:

>d3exfd1 c.36.1.7 (D:1-191) E1-beta subunit of pyruvate dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}
lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
efppeaqskdf

Timeline for d3exfd1:

• d3exfd1 is new in SCOPe 2.04-stable
  
• d3exfd1 appears in SCOPe 2.05
  
• d3exfd1 appears in the current release, SCOPe 2.08