SCOPe 2.05: Domain d2ziab_: 2zia B:

Lineage for d2ziab_ (2zia B:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Deoxycytidine kinase [89657] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89658] (41 PDB entries)

8. Domain d2ziab_: 2zia B: [244941]
   automated match to d1p60a_
   complexed with cl9, udp

Details for d2ziab_

PDB Entry: 2zia, 1.8 Å

PDB Description: c4s dck variant of dck in complex with cladribine+udp

PDB Compounds: (B:) Deoxycytidine kinase

SCOPe Domain Sequences for d2ziab_:

Sequence, based on SEQRES records:

>d2ziab_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmsqkngg
nvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifas
nlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqg
ipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflst
l

Sequence, based on observed residues (ATOM records):

>d2ziab_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstggnvlqmmyekperw
sftfqtyaclsriraqlaslnldaekpvlffersvysdryifasnlyesesmnetewtiy
qdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykhesw
llhrtltylqevpiltldvnedfkdkyeslvekvkeflstl

Timeline for d2ziab_:

• d2ziab_ first appeared in SCOPe 2.04
  
• d2ziab_ appears in SCOPe 2.06
  
• d2ziab_ appears in the current release, SCOPe 2.08