Lineage for d2xpka2 (2xpk A:179-495)

  1. Root: SCOPe 2.04
  2. 1565955Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1565956Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 1568602Superfamily c.1.8: (Trans)glycosidases [51445] (15 families) (S)
  5. 1570523Family c.1.8.10: alpha-D-glucuronidase/Hyaluronidase catalytic domain [82253] (4 proteins)
    Glycosyl hydrolase family 67, GH67; structurally related to GH20; contains extra C-terminal alpha-helical subdomain
  6. Protein automated matches [254553] (2 species)
    not a true protein
  7. 1570581Species Clostridium perfringens [TaxId:1502] [255690] (1 PDB entry)
  8. 1570582Domain d2xpka2: 2xpk A:179-495 [244577]
    Other proteins in same PDB: d2xpka1, d2xpka3, d2xpkb1, d2xpkb3
    automated match to d2v5ca2
    complexed with z0m

Details for d2xpka2

PDB Entry: 2xpk (more details), 2.4 Å

PDB Description: cell-penetrant, nanomolar o-glcnacase inhibitors selective against lysosomal hexosaminidases
PDB Compounds: (A:) O-GlcNAcase nagJ

SCOPe Domain Sequences for d2xpka2:

Sequence; same for both SEQRES and ATOM records: (download)

>d2xpka2 c.1.8.10 (A:179-495) automated matches {Clostridium perfringens [TaxId: 1502]}

SCOPe Domain Coordinates for d2xpka2:

Click to download the PDB-style file with coordinates for d2xpka2.
(The format of our PDB-style files is described here.)

Timeline for d2xpka2: