SCOPe 2.08: Domain d2q8ga2: 2q8g A:214-423

Lineage for d2q8ga2 (2q8g A:214-423)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.0: automated matches [227160] (1 protein)
   not a true family

6. Protein automated matches [226867] (22 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225008] (15 PDB entries)

8. Domain d2q8ga2: 2q8g A:214-423 [243527]
   Other proteins in same PDB: d2q8ga1
   automated match to d2bu8a2
   complexed with azx, k

Details for d2q8ga2

PDB Entry: 2q8g, 1.9 Å

PDB Description: structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug azd7545

PDB Compounds: (A:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1

SCOPe Domain Sequences for d2q8ga2:

Sequence, based on SEQRES records:

>d2q8ga2 d.122.1.0 (A:214-423) automated matches {Human (Homo sapiens) [TaxId: 9606]}
khigsinpncnvlevikdgyenarrlcdlyyinspeleleelnakspgqpiqvvyvpshl
yhmvfelfknamratmehhanrgvyppiqvhvtlgnedltvkmsdrgggvplrkidrlfn
ymystaprprvetsravplagfgyglpisrlyaqyfqgdlklyslegygtdaviyikals
tdsierlpvynkaawkhyntnheaddwcvp

Sequence, based on observed residues (ATOM records):

>d2q8ga2 d.122.1.0 (A:214-423) automated matches {Human (Homo sapiens) [TaxId: 9606]}
khigsinpncnvlevikdgyenarrlcdlyyinspeleleelnakspgqpiqvvyvpshl
yhmvfelfknamratmehhanrgvyppiqvhvtlgnedltvkmsdrgggvplrkidrlfn
ymystaprprvetsravplagfgyglpisrlyaqyfqgdlklyslegygtdaviyikals
tdsierlpvynkaawkhyntnddwcvp

Timeline for d2q8ga2:

• d2q8ga2 first appeared in SCOPe 2.04
  
• d2q8ga2 appears in SCOPe 2.07