Lineage for d2lq7a1 (2lq7 A:348-442)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2149982Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 2149983Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 2149990Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 protein domains)
    the common fold is elaborated with additional (sub)domains
  6. 2150022Protein UBA3 [89764] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
  7. 2150023Species Human (Homo sapiens) [TaxId:9606] [89765] (12 PDB entries)
    Uniprot Q8TBC4 33-458
  8. 2150053Domain d2lq7a1: 2lq7 A:348-442 [242963]
    Other proteins in same PDB: d2lq7a2
    automated match to d3fn1a_

Details for d2lq7a1

PDB Entry: 2lq7 (more details)

PDB Description: E2 binding surface on Uba3 beta-grasp domain undergoes a conformational transition
PDB Compounds: (A:) NEDD8-activating enzyme E1 catalytic subunit

SCOPe Domain Sequences for d2lq7a1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2lq7a1 c.111.1.2 (A:348-442) UBA3 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2lq7a1:

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Timeline for d2lq7a1:

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