SCOPe 2.08: Domain d2jita_: 2jit A:

Lineage for d2jita_ (2jit A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d2jita_: 2jit A: [242228]
   automated match to d3ikaa_
   mutant

Details for d2jita_

PDB Entry: 2jit, 3.1 Å

PDB Description: crystal structure of egfr kinase domain t790m mutation

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2jita_:

Sequence, based on SEQRES records:

>d2jita_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadey

Sequence, based on observed residues (ATOM records):

>d2jita_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgderdvvdadey

Timeline for d2jita_:

• d2jita_ first appeared in SCOPe 2.04
  
• d2jita_ appears in SCOPe 2.07