SCOPe 2.08: Domain d2hnzb_: 2hnz B:

Lineage for d2hnzb_ (2hnz B:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (206 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d2hnzb_: 2hnz B: [242052]
   Other proteins in same PDB: d2hnza2
   automated match to d1lweb_
   complexed with pc0, po4; mutant

Details for d2hnzb_

PDB Entry: 2hnz, 3 Å

PDB Description: crystal structure of e138k mutant hiv-1 reverse transcriptase in complex with pett-2

PDB Compounds: (B:) Reverse transcriptase/ribonuclease H

SCOPe Domain Sequences for d2hnzb_:

Sequence, based on SEQRES records:

>d2hnzb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsinnktpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivl
pekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaen
reilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvk
qlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklw
yq

Sequence, based on observed residues (ATOM records):

>d2hnzb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwphpaglkkkksvtvldvgdayfsvpldedfrkytafti
psinnktpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsd
leigqhrtkieelrqhllrwppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgkl
nwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskd
liaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktpkf
klpiqketwetwwteywqatwipewefvntpplvklwyq

Timeline for d2hnzb_:

• d2hnzb_ first appeared in SCOPe 2.04
  
• d2hnzb_ appears in SCOPe 2.07