SCOPe 2.08: Domain d2gp5a_: 2gp5 A:

Lineage for d2gp5a_ (2gp5 A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.14: Jumonji domain / Histone demethylase core [254153] (7 proteins)
   Jumonji domain; Pfam PF02375 (JmjN) and Pfam PF02373 (JmjC); relationship to FIH1 (b.82.2.6) described in PubMed 16983801
   Pfam PF02375 (JmjN) and Pfam PF02373 (JmjC); relationship to FIH1 (b.82.2.6) described in PubMed 16983801; some members include C-terminal helical subdomain (Pfam PF17811)

6. Protein JMJD2A core [254342] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [254775] (57 PDB entries)

8. Domain d2gp5a_: 2gp5 A: [241945]
   complexed with akg, fe2, zn

Details for d2gp5a_

PDB Entry: 2gp5, 2.28 Å

PDB Description: Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate

PDB Compounds: (A:) Jumonji domain-containing protein 2A

SCOPe Domain Sequences for d2gp5a_:

Sequence; same for both SEQRES and ATOM records:

>d2gp5a_ b.82.2.14 (A:) JMJD2A core {Human (Homo sapiens) [TaxId: 9606]}
asesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasydd
iddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerky
wknltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmw
ktsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhk
mtlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygk
qavlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptp

Timeline for d2gp5a_:

• d2gp5a_ first appeared in SCOPe 2.04
  
• d2gp5a_ appears in SCOPe 2.07