SCOPe 2.06: Domain d2bu5a2: 2bu5 A:178-385

Lineage for d2bu5a2 (2bu5 A:178-385)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein automated matches [230554] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [230555] (14 PDB entries)

8. Domain d2bu5a2: 2bu5 A:178-385 [241334]
   Other proteins in same PDB: d2bu5a1
   automated match to d2bu8a2
   complexed with tf1

Details for d2bu5a2

PDB Entry: 2bu5, 2.35 Å

PDB Description: crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

PDB Compounds: (A:) pyruvate dehydrogenase kinase isoenzyme 2

SCOPe Domain Sequences for d2bu5a2:

Sequence, based on SEQRES records:

>d2bu5a2 d.122.1.4 (A:178-385) automated matches {Human (Homo sapiens) [TaxId: 9606]}
khigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshl
yhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfs
ymystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalst
dsverlpvynksawrhyqtiqeagdwcv

Sequence, based on observed residues (ATOM records):

>d2bu5a2 d.122.1.4 (A:178-385) automated matches {Human (Homo sapiens) [TaxId: 9606]}
khigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshl
yhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfs
ymystapgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksaw
rhyqtiqeagdwcv

Timeline for d2bu5a2:

• d2bu5a2 first appeared in SCOPe 2.04
  
• d2bu5a2 appears in SCOPe 2.05
  
• d2bu5a2 appears in SCOPe 2.07
  
• d2bu5a2 appears in the current release, SCOPe 2.08