SCOPe 2.05: Domain d2bu2a2: 2bu2 A:177-385

Lineage for d2bu2a2 (2bu2 A:177-385)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein automated matches [230554] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [230555] (13 PDB entries)

8. Domain d2bu2a2: 2bu2 A:177-385 [241332]
   Other proteins in same PDB: d2bu2a1
   automated match to d2bu8a2
   complexed with atp, mg, tf1

Details for d2bu2a2

PDB Entry: 2bu2, 2.4 Å

PDB Description: crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

PDB Compounds: (A:) pyruvate dehydrogensae kinase isoenzyme 2

SCOPe Domain Sequences for d2bu2a2:

Sequence, based on SEQRES records:

>d2bu2a2 d.122.1.4 (A:177-385) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpsh
lyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlf
symystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkals
tdsverlpvynksawrhyqtiqeagdwcv

Sequence, based on observed residues (ATOM records):

>d2bu2a2 d.122.1.4 (A:177-385) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpsh
lyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlf
symystlagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynk
sawrhyqtiqeagdwcv

Timeline for d2bu2a2:

• d2bu2a2 first appeared in SCOPe 2.04
  
• d2bu2a2 appears in SCOPe 2.06
  
• d2bu2a2 appears in the current release, SCOPe 2.08