SCOPe 2.06: Domain d3pvwa3: 3pvw A:550-668

Lineage for d3pvwa3 (3pvw A:550-668)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
   barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix

4. Superfamily b.55.1: PH domain-like [50729] (14 families)

5. Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
   Pfam PF00169

6. Protein G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)

7. Species Cow (Bos taurus) [TaxId:9913] [89354] (6 PDB entries)

8. Domain d3pvwa3: 3pvw A:550-668 [239630]
   Other proteins in same PDB: d3pvwa1, d3pvwa2, d3pvwb_, d3pvwg_
   automated match to d1omwa2
   complexed with qrx

Details for d3pvwa3

PDB Entry: 3pvw, 2.49 Å

PDB Description: Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)

PDB Compounds: (A:) Beta-adrenergic receptor kinase 1

SCOPe Domain Sequences for d3pvwa3:

Sequence, based on SEQRES records:

>d3pvwa3 b.55.1.1 (A:550-668) G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) {Cow (Bos taurus) [TaxId: 9913]}
eedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqslltmeeiqsv
eetqikerkclllkirggkqfvlqcdsdpelvqwkkelrdayreaqqlvqrvpkmknkp

Sequence, based on observed residues (ATOM records):

>d3pvwa3 b.55.1.1 (A:550-668) G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) {Cow (Bos taurus) [TaxId: 9913]}
eedyalgkdcimhgymskmgwqrryfylfpnrlewrgegeapqslltmeeiqsveetqik
erkclllkirggkqfvlqcdsdpelvqwkkelrdayreaqqlvqrvpkmknkp

Timeline for d3pvwa3:

• d3pvwa3 first appeared in SCOPe 2.04
  
• d3pvwa3 appears in SCOPe 2.05
  
• d3pvwa3 appears in SCOPe 2.07
  
• d3pvwa3 appears in the current release, SCOPe 2.08