SCOPe 2.06: Domain d3pvua2: 3pvu A:186-549

Lineage for d3pvua2 (3pvu A:186-549)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein G-protein coupled receptor kinase 2 [90034] (1 species)
   AGC group; GRKs subfamily; serine/threonine kinase

7. Species Cow (Bos taurus) [TaxId:9913] [90035] (6 PDB entries)

8. Domain d3pvua2: 3pvu A:186-549 [239626]
   Other proteins in same PDB: d3pvua1, d3pvua3, d3pvub_, d3pvug_
   automated match to d1omwa3
   complexed with qrw

Details for d3pvua2

PDB Entry: 3pvu, 2.48 Å

PDB Description: Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)

PDB Compounds: (A:) Beta-adrenergic receptor kinase 1

SCOPe Domain Sequences for d3pvua2:

Sequence, based on SEQRES records:

>d3pvua2 d.144.1.7 (A:186-549) G-protein coupled receptor kinase 2 {Cow (Bos taurus) [TaxId: 9913]}
ltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalnerimlsl
vstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaaeiilgl
ehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymapevlqkg
vaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspelrsll
egllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaadafdi
gsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrlearkktknk
qlgh

Sequence, based on observed residues (ATOM records):

>d3pvua2 d.144.1.7 (A:186-549) G-protein coupled receptor kinase 2 {Cow (Bos taurus) [TaxId: 9913]}
ltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalnerimlsl
vstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaaeiilgl
ehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymapevlqkg
vaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspelrsll
egllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgdsdqelyrnf
pltiserwqqevaetvfdtinaetdrlearkktknkqlgh

Timeline for d3pvua2:

• d3pvua2 first appeared in SCOPe 2.04
  
• d3pvua2 appears in SCOPe 2.05
  
• d3pvua2 appears in SCOPe 2.07
  
• d3pvua2 appears in the current release, SCOPe 2.08