SCOPe 2.05: Domain d3psca2: 3psc A:186-549

Lineage for d3psca2 (3psc A:186-549)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein G-protein coupled receptor kinase 2 [90034] (1 species)
   AGC group; GRKs subfamily; serine/threonine kinase

7. Species Cow (Bos taurus) [TaxId:9913] [90035] (6 PDB entries)

8. Domain d3psca2: 3psc A:186-549 [239623]
   Other proteins in same PDB: d3psca1, d3psca3, d3pscb_, d3pscg_
   automated match to d1omwa3

Details for d3psca2

PDB Entry: 3psc, 2.67 Å

PDB Description: Bovine GRK2 in complex with Gbetagamma subunits

PDB Compounds: (A:) Beta-adrenergic receptor kinase 1

SCOPe Domain Sequences for d3psca2:

Sequence, based on SEQRES records:

>d3psca2 d.144.1.7 (A:186-549) G-protein coupled receptor kinase 2 {Cow (Bos taurus) [TaxId: 9913]}
ltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalnerimlsl
vstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaaeiilgl
ehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymapevlqkg
vaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspelrsll
egllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaadafdi
gsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrlearkktknk
qlgh

Sequence, based on observed residues (ATOM records):

>d3psca2 d.144.1.7 (A:186-549) G-protein coupled receptor kinase 2 {Cow (Bos taurus) [TaxId: 9913]}
ltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalnerimlsl
vstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaaeiilgl
ehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymapevlqkg
vaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspelrsll
egllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgiklldsdqel
yrnfpltiserwqqevaetvfdtinaetdrlearkktknkqlgh

Timeline for d3psca2:

• d3psca2 first appeared in SCOPe 2.04
  
• d3psca2 appears in SCOPe 2.06
  
• d3psca2 appears in the current release, SCOPe 2.08