SCOPe 2.05: Domain d1g88c_: 1g88 C:

Lineage for d1g88c_ (1g88 C:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.26: SMAD/FHA domain [49878] (1 superfamily)
   sandwich; 11 strands in 2 sheets; greek-key

4. Superfamily b.26.1: SMAD/FHA domain [49879] (5 families)
   has a few short helices inserted in loops

5. Family b.26.1.1: SMAD domain [49880] (4 proteins)

6. Protein Smad4 tumor suppressor C-terminal domain [49881] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49882] (6 PDB entries)
   Uniprot Q13485 314-546

8. Domain d1g88c_: 1g88 C: [23913]
   mutant

Details for d1g88c_

PDB Entry: 1g88, 3 Å

PDB Description: s4afl3arg515 mutant

PDB Compounds: (C:) smad4

SCOPe Domain Sequences for d1g88c_:

Sequence, based on SEQRES records:

>d1g88c_ b.26.1.1 (C:) Smad4 tumor suppressor C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
nghlqhhppmpphpghywpvhnelafqppisnhpapeywcsiayfemdvqvgetfkvpss
cpivtvdgyvdpsggdrfclgqlsnvhrteaierarlhigkgvqleckgegdvwvrclsd
havfvqsyyldreagrapgdavhkiypsayikvfdlrqchrqmqqqaataqaaaaaqaaa
vagnipgpgsvggiapaislsaaagigvddlrrlcilrmsfvkgwgpdypsqsiketpcw
ieihlhralqlldevlhtmpiadpqp

Sequence, based on observed residues (ATOM records):

>d1g88c_ b.26.1.1 (C:) Smad4 tumor suppressor C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
nghlqhhppmppisnhpapeywcsiayfemdvqvgetfkvpsscpivtvdgyvdpsggdr
fclgqlsnvhrteaierarlhigkgvqleckgegdvwvrclsdhavfvqsyyldreagra
pgdavhkiypsayikvfdlrqchrqmqqqaataqaaaaaqaaavapaislsaaagigvdd
lrrlcilrmsfvkgwgpdypsqsiketpcwieihlhralqlldevlhtmpiadpqp

Timeline for d1g88c_:

• d1g88c_ first appeared (with stable ids) in SCOP 1.55
  
• d1g88c_ appears in SCOPe 2.04
  
• d1g88c_ appears in SCOPe 2.06
  
• d1g88c_ appears in the current release, SCOPe 2.08