SCOPe 2.08: Domain d1ygsa_: 1ygs A:

Lineage for d1ygsa_ (1ygs A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.26: SMAD/FHA domain [49878] (1 superfamily)
   sandwich; 11 strands in 2 sheets; greek-key

4. Superfamily b.26.1: SMAD/FHA domain [49879] (5 families)
   has a few short helices inserted in loops

5. Family b.26.1.1: SMAD domain [49880] (5 proteins)

6. Protein Smad4 tumor suppressor C-terminal domain [49881] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49882] (6 PDB entries)
   Uniprot Q13485 314-546

8. Domain d1ygsa_: 1ygs A: [23907]

Details for d1ygsa_

PDB Entry: 1ygs, 2.1 Å

PDB Description: crystal structure of the smad4 tumor suppressor c-terminal domain

PDB Compounds: (A:) smad4

SCOPe Domain Sequences for d1ygsa_:

Sequence, based on SEQRES records:

>d1ygsa_ b.26.1.1 (A:) Smad4 tumor suppressor C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
apeywcsiayfemdvqvgetfkvpsscpivtvdgyvdpsggdrfclgqlsnvhrteaier
arlhigkgvqleckgegdvwvrclsdhavfvqsyyldreagrapgdavhkiypsayikvf
dlrqchrqmqqqaataqaaaaaqaaavagnipgpgsvggiapaislsaaagigvddlrrl
cilrmsfvkgwgpdyprqsiketpcwieihlhralqlldevlhtm

Sequence, based on observed residues (ATOM records):

>d1ygsa_ b.26.1.1 (A:) Smad4 tumor suppressor C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
apeywcsiayfemdvqvgetfkvpsscpivtvdgyvdpsggdrfclgqlsnvhrteaier
arlhigkgvqleckgegdvwvrclsdhavfvqsyyldreagrapgdavhkiypsayikvf
dlrqchrqmqqqaataqavddlrrlcilrmsfvkgwgpdyprqsiketpcwieihlhral
qlldevlhtm

Timeline for d1ygsa_:

• d1ygsa_ first appeared (with stable ids) in SCOP 1.55, called d1ygs__
  
• d1ygsa_ appears in SCOPe 2.07