SCOPe 2.08: Domain d2w2dd2: 2w2d D:548-873

Lineage for d2w2dd2 (2w2d D:548-873)

1. Root: SCOPe 2.08

2. Class h: Coiled coil proteins [57942] (7 folds)

3. Fold h.4: Antiparallel coiled-coil [58086] (19 superfamilies)
   this is not a true fold; contains at least two very long antiparallel helices

4. Superfamily h.4.2: Clostridium neurotoxins, 'coiled-coil' domain [58091] (1 family)

5. Family h.4.2.1: Clostridium neurotoxins, 'coiled-coil' domain [58092] (1 protein)

6. Protein Botulinum neurotoxin [58093] (2 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [58094] (3 PDB entries)

8. Domain d2w2dd2: 2w2d D:548-873 [238895]
   Other proteins in same PDB: d2w2db1, d2w2db3, d2w2dd1, d2w2dd3
   complexed with act, cl, gol, so4, zn

Details for d2w2dd2

PDB Entry: 2w2d, 2.59 Å

PDB Description: crystal structure of a catalytically active, non-toxic endopeptidase derivative of clostridium botulinum toxin a

PDB Compounds: (D:) botulinum neurotoxin a heavy chain

SCOPe Domain Sequences for d2w2dd2:

Sequence, based on SEQRES records:

>d2w2dd2 h.4.2.1 (D:548-873) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
ytmfhylraqefehgksrialtnsvneallnpsrvytffssdyvkkvnkateaamflgwv
eqlvydftdetsevsttdkiaditiiipyigpalnignmlykddfvgalifsgavillef
ipeiaipvlgtfalvsyiankvltvqtidnalskrnekwdevykyivtnwlakvntqidl
irkkmkealenqaeatkaiinyqynqyteeeknninfniddlssklnesinkamininkf
lnqcsvsylmnsmipygvkrledfdaslkdallkyiydnrgtligqvdrlkdkvnntlst
dipfqlskyvdnqrllstfteyikni

Sequence, based on observed residues (ATOM records):

>d2w2dd2 h.4.2.1 (D:548-873) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
ytmfhylraqefehrialtnsvnealpsrvytffssdyvkkveaamflgwveqlvydftd
etsevstditiiipyigpalnignmlkddfvgalifsgavillefipeiaipvlgtfalv
syiankvltvqtidnalskrnekwdevykyivtnwlakvntqidlirkkmkealenqaea
tkaiinyqynqyteeeknnfniddlssklnesinkamininkflnqcsvsylmnsmipyg
vkrledfdaslkdallkyiydnrgtligqvdrlkdkvnntlstdipfqlskyvdnqrlls
tfteyikni

Timeline for d2w2dd2:

• d2w2dd2 first appeared in SCOPe 2.04
  
• d2w2dd2 appears in SCOPe 2.07