SCOPe 2.07: Domain d2ocfa_: 2ocf A:

Lineage for d2ocfa_ (2ocf A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (82 PDB entries)
   Uniprot P03372 307-551

8. Domain d2ocfa_: 2ocf A: [238772]
   Other proteins in same PDB: d2ocfd_
   automated match to d3q95b_
   complexed with est

Details for d2ocfa_

PDB Entry: 2ocf, 2.95 Å

PDB Description: human estrogen receptor alpha ligand-binding domain in complex with estradiol and the e2#23 fn3 monobody

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2ocfa_:

Sequence, based on SEQRES records:

>d2ocfa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdllleml
dahr

Sequence, based on observed residues (ATOM records):

>d2ocfa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagl
tlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

Timeline for d2ocfa_:

• d2ocfa_ first appeared in SCOPe 2.04
  
• d2ocfa_ appears in SCOPe 2.06
  
• d2ocfa_ appears in the current release, SCOPe 2.08