Lineage for d4k26b_ (4k26 B:)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2426096Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2426097Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2426443Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2426470Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2426592Species Mouse (Mus musculus) [TaxId:10090] [141879] (6 PDB entries)
    Uniprot P50172 24-298
  8. 2426596Domain d4k26b_: 4k26 B: [238395]
    automated match to d1y5ma1
    complexed with ndp, sff, so4

Details for d4k26b_

PDB Entry: 4k26 (more details), 2.21 Å

PDB Description: 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes
PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d4k26b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4k26b_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Mouse (Mus musculus) [TaxId: 10090]}

SCOPe Domain Coordinates for d4k26b_:

Click to download the PDB-style file with coordinates for d4k26b_.
(The format of our PDB-style files is described here.)

Timeline for d4k26b_: