Lineage for d4k1lb1 (4k1l B:24-285)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2090580Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2090596Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845
  8. 2090622Domain d4k1lb1: 4k1l B:24-285 [238387]
    Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
    automated match to d1xu9b_
    complexed with ndp, sff

Details for d4k1lb1

PDB Entry: 4k1l (more details), 1.96 Å

PDB Description: 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes
PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d4k1lb1:

Sequence; same for both SEQRES and ATOM records: (download)

>d4k1lb1 c.2.1.2 (B:24-285) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4k1lb1:

Click to download the PDB-style file with coordinates for d4k1lb1.
(The format of our PDB-style files is described here.)

Timeline for d4k1lb1: