SCOPe 2.03: Domain d4otwa_: 4otw A:

Lineage for d4otwa_ (4otw A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d4otwa_: 4otw A: [238305]
   automated match to d4asza_
   complexed with db8

Details for d4otwa_

PDB Entry: 4otw, 2.51 Å

PDB Description: her3 pseudokinase domain bound to bosutinib

PDB Compounds: (A:) Receptor tyrosine-protein kinase erbB-3

SCOPe Domain Sequences for d4otwa_:

Sequence, based on SEQRES records:

>d4otwa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwm
alesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpqicti
dvymvmvkcwmidenirptfkelaneftrmardpprylvik

Sequence, based on observed residues (ATOM records):

>d4otwa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppdktpikwmalesihfgk
ythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpqictidvymvmvkc
wmidenirptfkelaneftrmardpprylvik

Timeline for d4otwa_:

• d4otwa_ is new in SCOPe 2.03-stable
  
• d4otwa_ appears in SCOPe 2.04
  
• d4otwa_ last appears in SCOPe 2.07