SCOPe 2.08: Domain d4oksb2: 4oks B:326-630

Lineage for d4oksb2 (4oks B:326-630)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.14: RNA helicase [52724] (7 proteins)
   duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

6. Protein HCV helicase domain, C-terminal domain [418963] (1 species)

7. Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [419425] (15 PDB entries)

8. Domain d4oksb2: 4oks B:326-630 [238291]
   Other proteins in same PDB: d4oksa1, d4oksb1
   automated match to d4ojqa2
   complexed with 2t9, ca
   has additional subdomain(s) that are not in the common domain

Details for d4oksb2

PDB Entry: 4oks, 2.25 Å

PDB Description: Crystal Structure of Hepatitis C Virus NS3 Helicase Inhibitor Co-complex with Compound 19 [[6-(3,5-diaminophenyl)-1-(2-methoxy-5-nitrobenzyl)-1H-indol-3-yl]acetic acid]

PDB Compounds: (B:) Serine protease NS3

SCOPe Domain Sequences for d4oksb2:

Sequence, based on SEQRES records:

>d4oksb2 c.37.1.14 (B:326-630) HCV helicase domain, C-terminal domain {Human hepatitis C virus (HCV), different isolates [TaxId: 11103]}
pgsvtvshpnieevalsttgeipfygkaiplevikggrhlifchskkkcdelaaklvalg
inavayyrgldvsviptngdvvvvstdalmtgftgdfdsvidcntcvtqtvdfsldptft
ietttlpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvlcecydagcawyelm
paettvrlraymntpglpvcqdhlefwegvftglthidahflsqtkqsgenfpylvayqa
tvcaraqapppswdqmwkclirlkptlhgptpllyrlgavqnevtlthpitkyimtcmsa
dlevv

Sequence, based on observed residues (ATOM records):

>d4oksb2 c.37.1.14 (B:326-630) HCV helicase domain, C-terminal domain {Human hepatitis C virus (HCV), different isolates [TaxId: 11103]}
pgsvtvshpnieevalsttgeipfygkaiplevikggrhlifchskkkcdelaaklvalg
inavayyrgldvsviptngdvvvvstdalmgdfdsvidcntcvtqtvdfsldptftiett
tlpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvlcecydagcawyelmpaet
tvrlraymntpglpvcqdhlefwegvftglthidahflsqtkqsgenfpylvayqatvca
raqapppswdqmwkclirlkptlhgptpllyrlgavqnevtlthpitkyimtcmsadlev
v

Timeline for d4oksb2:

• d4oksb2 first appeared in SCOPe 2.03
  
• d4oksb2 appears in SCOPe 2.07