SCOPe 2.05: Domain d4igsa_: 4igs A:

Lineage for d4igsa_ (4igs A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (119 PDB entries)
   Uniprot P15121

8. Domain d4igsa_: 4igs A: [237811]
   automated match to d1pwma_
   complexed with 64i, nap

Details for d4igsa_

PDB Entry: 4igs, 0.85 Å

PDB Description: crystal structure of human aldose reductase complexed with nadp+ and jf0064

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d4igsa_:

Sequence; same for both SEQRES and ATOM records:

>d4igsa_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef

Timeline for d4igsa_:

• d4igsa_ first appeared in SCOPe 2.03
  
• d4igsa_ appears in SCOPe 2.04
  
• d4igsa_ appears in SCOPe 2.06
  
• d4igsa_ appears in the current release, SCOPe 2.08