SCOPe 2.08: Domain d4nyis_: 4nyi S:

Lineage for d4nyis_ (4nyi S:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.117: Ras GEF [48365] (1 superfamily)
   multihelical

4. Superfamily a.117.1: Ras GEF [48366] (1 family)

5. Family a.117.1.1: Ras GEF [48367] (2 proteins)

6. Protein Son of sevenless protein homolog 1 (sos-1) [48368] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48369] (60 PDB entries)
   Uniprot Q07889 189-1046

8. Domain d4nyis_: 4nyi S: [237692]
   Other proteins in same PDB: d4nyiq1, d4nyiq2, d4nyir1, d4nyir2
   automated match to d1nvus_
   complexed with 2px, gnp, mg

Details for d4nyis_

PDB Entry: 4nyi, 2.96 Å

PDB Description: Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange

PDB Compounds: (S:) Son of sevenless homolog 1

SCOPe Domain Sequences for d4nyis_:

Sequence, based on SEQRES records:

>d4nyis_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp
r

Sequence, based on observed residues (ATOM records):

>d4nyis_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
qmrlpsadvyrfaepdseeniifeenmagipiikagtviklierltyhmyadpnfvrtfl
ttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlr
vlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiahnitf
qsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedk
einspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlev
vsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyl
tnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenl
npmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr

Timeline for d4nyis_:

• d4nyis_ first appeared in SCOPe 2.03
  
• d4nyis_ appears in SCOPe 2.07