SCOPe 2.03: Domain d4ci9a_: 4ci9 A:

Lineage for d4ci9a_ (4ci9 A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.5: Serine carboxypeptidase-like [53499] (4 proteins)
   automatically mapped to Pfam PF00450

6. Protein Human 'protective protein', HPP [53504] (1 species)
   synonyms: cathepsin A, carboxypeptidase L

7. Species Human (Homo sapiens) [TaxId:9606] [53505] (4 PDB entries)

8. Domain d4ci9a_: 4ci9 A: [237120]
   automated match to d1ivya_
   complexed with act, dms, gol, so4

Details for d4ci9a_

PDB Entry: 4ci9, 1.58 Å

PDB Description: crystal structure of cathepsin a, apo-structure

PDB Compounds: (A:) lysosomal protective protein

SCOPe Domain Sequences for d4ci9a_:

Sequence, based on SEQRES records:

>d4ci9a_ c.69.1.5 (A:) Human 'protective protein', HPP {Human (Homo sapiens) [TaxId: 9606]}
srapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggp
gcssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatnd
tevaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgn
glssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevari
vgnsglniynlyapcaggvpshfryekdtvvvqdlgniftrlplkrmwhqallrsgdkvr
mdppctnttaastylnnpyvrkalnipeqlpqwdmcnflvnlqyrrlyrsmnsqylklls
sqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwlvkygdsgeqiagfvkefsh
iafltikgaghmvptdkplaaftmfsrflnkqpye

Sequence, based on observed residues (ATOM records):

>d4ci9a_ c.69.1.5 (A:) Human 'protective protein', HPP {Human (Homo sapiens) [TaxId: 9606]}
srapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggp
gcssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatnd
tevaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgn
glssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevari
vgnsglniynlyapcaggvpsdppctnttaastylnnpyvrkalnipeqlpqwdmcnflv
nlqyrrlyrsmnsqylkllssqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpw
lvkygdsgeqiagfvkefshiafltikgaghmvptdkplaaftmfsrflnkqpye

Timeline for d4ci9a_:

• d4ci9a_ is new in SCOPe 2.03-stable
  
• d4ci9a_ appears in SCOPe 2.04
  
• d4ci9a_ appears in the current release, SCOPe 2.08, called d4ci9a1