SCOPe 2.07: Domain d4ciba1: 4cib A:1-452

Lineage for d4ciba1 (4cib A:1-452)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.5: Serine carboxypeptidase-like [53499] (4 proteins)
   automatically mapped to Pfam PF00450

6. Protein Human 'protective protein', HPP [53504] (1 species)
   synonyms: cathepsin A, carboxypeptidase L

7. Species Human (Homo sapiens) [TaxId:9606] [53505] (5 PDB entries)

8. Domain d4ciba1: 4cib A:1-452 [237119]
   Other proteins in same PDB: d4ciba2, d4ciba3
   automated match to d1ivya_
   complexed with 7uz, cd

Details for d4ciba1

PDB Entry: 4cib, 1.89 Å

PDB Description: crystal structure of cathepsin a, complexed with compound 2

PDB Compounds: (A:) lysosomal protective protein

SCOPe Domain Sequences for d4ciba1:

Sequence, based on SEQRES records:

>d4ciba1 c.69.1.5 (A:1-452) Human 'protective protein', HPP {Human (Homo sapiens) [TaxId: 9606]}
apdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggpgc
ssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatndte
vaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgngl
ssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevarivg
nsglniynlyapcaggvpshfryekdtvvvqdlgniftrlplkrmwhqallrsgdkvrmd
ppctnttaastylnnpyvrkalnipeqlpqwdmcnflvnlqyrrlyrsmnsqylkllssq
kyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwlvkygdsgeqiagfvkefshia
fltikgaghmvptdkplaaftmfsrflnkqpy

Sequence, based on observed residues (ATOM records):

>d4ciba1 c.69.1.5 (A:1-452) Human 'protective protein', HPP {Human (Homo sapiens) [TaxId: 9606]}
apdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggpgc
ssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatndte
vaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgngl
ssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevarivg
nsglniynlyapcaggvpsdppctnttaastylnnpyvrkalnipeqlpqwdmcnflvnl
qyrrlyrsmnsqylkllssqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwlv
kygsgeqiagfvkefshiafltikgaghmvptdkplaaftmfsrflnkqpy

Timeline for d4ciba1:

• d4ciba1 first appeared in SCOPe 2.03, called d4ciba_
  
• d4ciba1 appears in SCOPe 2.06
  
• d4ciba1 appears in the current release, SCOPe 2.08