SCOPe 2.08: Domain d3weka_: 3wek A:

Lineage for d3weka_ (3wek A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.2: Squalene synthase [48580] (2 proteins)
   automatically mapped to Pfam PF00494

6. Protein automated matches [191305] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [190011] (24 PDB entries)

8. Domain d3weka_: 3wek A: [236942]
   automated match to d3vjbc_
   complexed with mg, ps7; mutant

Details for d3weka_

PDB Entry: 3wek, 1.85 Å

PDB Description: crystal structure of the human squalene synthase f288l mutant in complex with presqualene pyrophosphate

PDB Compounds: (A:) Squalene synthase

SCOPe Domain Sequences for d3weka_:

Sequence; same for both SEQRES and ATOM records:

>d3weka_ a.128.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
slssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkv
pllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigm
aefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqkt
niirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvi
tylsrlrnqsvfnlcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpav
kaiiyqymeeiyhripdsdpsssktrqiistirtq

Timeline for d3weka_:

• d3weka_ first appeared in SCOPe 2.03
  
• d3weka_ appears in SCOPe 2.07