SCOPe 2.08: Domain d4ccua_: 4ccu A:

Lineage for d4ccua_ (4ccu A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4ccua_: 4ccu A: [236304]
   automated match to d2xp2a_
   complexed with awf

Details for d4ccua_

PDB Entry: 4ccu, 2 Å

PDB Description: structure of the human anaplastic lymphoma kinase in complex with 2- (5-(6-amino-5-((r)-1-(5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl) ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol

PDB Compounds: (A:) ALK tyrosine kinase receptor

SCOPe Domain Sequences for d4ccua_:

Sequence, based on SEQRES records:

>d4ccua_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktl
pevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretr
prpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfg
mardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympyps
ksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdv
intalpieyg

Sequence, based on observed residues (ATOM records):

>d4ccua_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgevyegqvplqvavktlpevcseqdeld
flmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrggca
mlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmd
ppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg

Timeline for d4ccua_:

• d4ccua_ first appeared in SCOPe 2.03
  
• d4ccua_ appears in SCOPe 2.07