Lineage for d4ccua_ (4ccu A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2546221Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2546222Protein automated matches [190417] (29 species)
    not a true protein
  7. 2546365Species Human (Homo sapiens) [TaxId:9606] [187294] (1053 PDB entries)
  8. 2546730Domain d4ccua_: 4ccu A: [236304]
    automated match to d2xp2a_
    complexed with awf

Details for d4ccua_

PDB Entry: 4ccu (more details), 2 Å

PDB Description: Structure of the Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol
PDB Compounds: (A:) ALK tyrosine kinase receptor

SCOPe Domain Sequences for d4ccua_:

Sequence, based on SEQRES records: (download)

>d4ccua_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktl
pevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretr
prpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfg
mardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympyps
ksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdv
intalpieyg

Sequence, based on observed residues (ATOM records): (download)

>d4ccua_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgevyegqvplqvavktlpevcseqdeld
flmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrggca
mlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmd
ppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg

SCOPe Domain Coordinates for d4ccua_:

Click to download the PDB-style file with coordinates for d4ccua_.
(The format of our PDB-style files is described here.)

Timeline for d4ccua_: