SCOPe 2.08: Domain d4kbkc_: 4kbk C:

Lineage for d4kbkc_ (4kbk C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Casein kinase-1, CK1 [56139] (4 species)
   OPK group; CKI subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [224941] (25 PDB entries)

8. Domain d4kbkc_: 4kbk C: [235138]
   automated match to d4kbad_
   complexed with 1qg, so4

Details for d4kbkc_

PDB Entry: 4kbk, 2.1 Å

PDB Description: CK1d in complex with (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}morpholine inhibitor

PDB Compounds: (C:) Casein kinase I isoform delta

SCOPe Domain Sequences for d4kbkc_:

Sequence, based on SEQRES records:

>d4kbkc_ d.144.1.7 (C:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
rvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggv
giptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihskn
fihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasin
thlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckg
ypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

Sequence, based on observed residues (ATOM records):

>d4kbkc_ d.144.1.7 (C:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
rvgnryrlgrkigsgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgip
tirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfih
rdvkpdnflmglgkkgnlvyiidfglakkyhipyrenknltgtaryasinthlgieqsrr
ddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatyln
fcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

Timeline for d4kbkc_:

• d4kbkc_ first appeared in SCOPe 2.03
  
• d4kbkc_ appears in SCOPe 2.07