SCOPe 2.04: Domain d4kbac_: 4kba C:

Lineage for d4kbac_ (4kba C:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Casein kinase-1, CK1 [56139] (4 species)
   OPK group; CKI subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [224941] (8 PDB entries)

8. Domain d4kbac_: 4kba C: [235130]
   automated match to d4kbad_
   complexed with 1qm, so4

Details for d4kbac_

PDB Entry: 4kba, 1.98 Å

PDB Description: CK1d in complex with 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine inhibitor

PDB Compounds: (C:) Casein kinase I isoform delta

SCOPe Domain Sequences for d4kbac_:

Sequence, based on SEQRES records:

>d4kbac_ d.144.1.7 (C:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
nryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgip
tirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfih
rdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthl
gieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgyps
efatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

Sequence, based on observed residues (ATOM records):

>d4kbac_ d.144.1.7 (C:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
nryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgip
tirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfih
rdvkpdnflmglgkkgnlvyiidfglakkyyrenknltgtaryasinthlgieqsrrddl
eslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatylnfcr
slrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

Timeline for d4kbac_:

• d4kbac_ first appeared in SCOPe 2.03
  
• d4kbac_ appears in SCOPe 2.05
  
• d4kbac_ appears in the current release, SCOPe 2.08