SCOPe 2.05: Domain d4kaba_: 4kab A:

Lineage for d4kaba_ (4kab A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Focal adhesion kinase 1 (fak) [103292] (2 species)
   PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103293] (15 PDB entries)

8. Domain d4kaba_: 4kab A: [235128]
   automated match to d4gu9a_
   complexed with 4ka

Details for d4kaba_

PDB Entry: 4kab, 2.71 Å

PDB Description: focal adhesion kinase catalytic domain in complex with 3-methyl-1,4-dihydro-pyrazolo[4,5-c]pyrazole

PDB Compounds: (A:) Focal adhesion kinase 1

SCOPe Domain Sequences for d4kaba_:

Sequence, based on SEQRES records:

>d4kaba_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
trdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqe
altmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqls
talayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmap
esinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptl
yslmtkcwaydpsrrprftelkaqlstileeekaq

Sequence, based on observed residues (ATOM records):

>d4kaba_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
trdyeiqrerielgrcigegqfgdvhqgiymsppalavaiktcknctsdsvrekflqeal
tmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlsta
layleskrfvhrdiaarnvlvssndcvklgdflpikwmapesinfrrftsasdvwmfgvc
mweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprfte
lkaqlstileeekaq

Timeline for d4kaba_:

• d4kaba_ first appeared in SCOPe 2.03
  
• d4kaba_ appears in SCOPe 2.04
  
• d4kaba_ appears in SCOPe 2.06
  
• d4kaba_ appears in the current release, SCOPe 2.08