Lineage for d4k8ab_ (4k8a B:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1930471Protein Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
  7. 1930475Species Human (Homo sapiens) [TaxId:9606] [103293] (15 PDB entries)
  8. 1930497Domain d4k8ab_: 4k8a B: [235118]
    automated match to d4gu9a_
    complexed with k8a

Details for d4k8ab_

PDB Entry: 4k8a (more details), 2.91 Å

PDB Description: Fragment-based discovery of Focal Adhesion Kinase Inhibitors
PDB Compounds: (B:) Focal adhesion kinase 1

SCOPe Domain Sequences for d4k8ab_:

Sequence, based on SEQRES records: (download)

>d4k8ab_ d.144.1.7 (B:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
dyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqeal
tmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlsta
layleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmapes
infrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlys
lmtkcwaydpsrrprftelkaqlstileeek

Sequence, based on observed residues (ATOM records): (download)

>d4k8ab_ d.144.1.7 (B:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
dyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqeal
tmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlsta
layleskrfvhrdiaarnvlvssndcvklgdfglsrylpikwmapesinfrrftsasdvw
mfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrr
prftelkaqlstileeek

SCOPe Domain Coordinates for d4k8ab_:

Click to download the PDB-style file with coordinates for d4k8ab_.
(The format of our PDB-style files is described here.)

Timeline for d4k8ab_: