SCOPe 2.05: Domain d4k4rb_: 4k4r B:

Lineage for d4k4rb_ (4k4r B:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (8 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (446 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d4k4rb_: 4k4r B: [235095]
   automated match to d4k4qa_
   complexed with 27b, 3tl, br, dms, no3

Details for d4k4rb_

PDB Entry: 4k4r, 1.8 Å

PDB Description: TL-3 inhibited Trp6Ala HIV Protease with 1-bromo-2-napthoic acid bound in exosite

PDB Compounds: (B:) Gag-Pol polyprotein

SCOPe Domain Sequences for d4k4rb_:

Sequence; same for both SEQRES and ATOM records:

>d4k4rb_ b.50.1.1 (B:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlakrplvtikiggqlkealldtgaddtvleemnlpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d4k4rb_:

• d4k4rb_ first appeared in SCOPe 2.03
  
• d4k4rb_ appears in SCOPe 2.04
  
• d4k4rb_ appears in SCOPe 2.06
  
• d4k4rb_ appears in the current release, SCOPe 2.08