SCOPe 2.06: Domain d4h6ta_: 4h6t A:

Lineage for d4h6ta_ (4h6t A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (170 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d4h6ta_: 4h6t A: [234623]
   automated match to d3k65b_
   complexed with po4; mutant

Details for d4h6ta_

PDB Entry: 4h6t, 2.4 Å

PDB Description: Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A

PDB Compounds: (A:) Prothrombin

SCOPe Domain Sequences for d4h6ta_:

Sequence, based on SEQRES records:

>d4h6ta_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
tseyqtffnprtfgsgeadcglrplfekksledkterallesyiagrivagsdaeigmsp
wqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryer
niekismlekiyihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqag
ykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpd
egkrgdacegdaggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkv
idqfge

Sequence, based on observed residues (ATOM records):

>d4h6ta_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
tseyqtffnprtfgsgeadcglrplfekksledkterallesyiagrivagsdaeigmsp
wqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryer
niekismlekiyihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqag
ykgrvtgwgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdag
gpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfge

Timeline for d4h6ta_:

• d4h6ta_ first appeared in SCOPe 2.03
  
• d4h6ta_ appears in SCOPe 2.05
  
• d4h6ta_ appears in SCOPe 2.07
  
• d4h6ta_ appears in the current release, SCOPe 2.08