SCOPe 2.03: Domain d4gd7a_: 4gd7 A:

Lineage for d4gd7a_ (4gd7 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (12 PDB entries)

8. Domain d4gd7a_: 4gd7 A: [234462]
   automated match to d1hw3a_
   complexed with edo, so4, tiy

Details for d4gd7a_

PDB Entry: 4gd7, 2.29 Å

PDB Description: Wild-Type Human Thymidylate Synthase with bound Purpurogallin

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d4gd7a_:

Sequence, based on SEQRES records:

>d4gd7a_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
phgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaey
rdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvns
elscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplk
iqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

Sequence, based on observed residues (ATOM records):

>d4gd7a_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
phgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqg
vdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsg
dmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfp
klrilrkvekiddfkaedfqiegynphptikme

Timeline for d4gd7a_:

• d4gd7a_ is new in SCOPe 2.03-stable
  
• d4gd7a_ appears in SCOPe 2.04
  
• d4gd7a_ appears in the current release, SCOPe 2.08